Biodistribution study protocol ethics

Biodistribution of nanoparticles: Initial considerations ...

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The Ethics Review Board and Animal Ethics Committee of University Hospital Clementino Fraga Filho (Radiopharmacy) of the Federal University of Rio de Janeiro (Rio de Janeiro, Brazil) approved the study protocol. 2.1. Nanoparticles. Six samples of nanoparticles were analyzed. ... The use of biodistribution study by radiolabeling methodology was ...

Biodistribution of nanoparticles: Initial considerations ...

Effect of obesity on biodistribution of nanoparticles ...

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7/10/2018 · The Institutional Review Board and the Animal Ethics Committee approved the study protocol. Table 1. Distribution of number of animals (n) used for the biodistribution study with radiolabeled nanoparticles (magnetic core mesoporous silica and polycaprolactone ethambutol) into the two groups: obese and nonobese (lean) mice. ...

Effect of obesity on biodistribution of nanoparticles ...

Preclinical good laboratory practice-compliant safety ...

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5/20/2015 · The clinical development of advanced therapy medicinal products (ATMPs), a new class of drugs, requires initial safety studies that deviate from standard non-clinical safety protocols. The study provides a strategy to address the safety aspects of biodistribution and tumorigenicity of ATMPs under good laboratory practice (GLP) conditions ...

Preclinical good laboratory practice-compliant safety ...

Biodistribution, Stability, and Blood Distribution of the ...

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The in vivo 125 I-Tyr-MCa biodistribution experiments reported in the present study were performed at blood peptide concentrations in the range of 1 µM which are therefore representative of the effective concentrations required for cell penetration and pharmacological action . The present study led to several interesting conclusions.

Biodistribution, Stability, and Blood Distribution of the ...

Comparative biodistribution analysis across four different ...

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Before this harmonization protocol became available, it was not possible to compare the biodistribution of 89 Zr-labeled mAbs assessed by PET. Comparison between the biodistribution of antibodies was also hampered by the lack of a standard delineation protocol when performing the semi-quantitative analyses.

Comparative biodistribution analysis across four different ...

The Biodistribution (I): Preclinical - ResearchGate

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The Biodistribution (I): Preclinical. ... contribute to a better understanding of the correlation of biodistribution study results and organ-tumor toxicity information. ... a checklist for study ...

The Biodistribution (I): Preclinical - ResearchGate

A Phase 1, Open-Label Study of the Biodistribution ...

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9/1/2015 · This clinical trial (NCT00667537) was approved by the appropriate ethics committees and was conducted in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All study subjects gave a signature of written informed consent.

A Phase 1, Open-Label Study of the Biodistribution ...

Biodistribution and Radiation Dosimetry of the Amyloid ...

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1/1/2007 · Subjects. The protocol of this study was approved by the local ethics committee and the Finnish National Agency for Medicines. Eight healthy male volunteers, 22- to 42-y old (mean ± SD, 27.5 ± 6.7 y; median age, 27 y), were recruited for dynamic PET of the upper or middle abdominal region or the entire body after written informed consent was given.

Biodistribution and Radiation Dosimetry of the Amyloid ...

RESEARCH ARTICLE Preparation, Pharmacokinetics ...

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In the present study, the pharmacokinetics, biodistribution, antitumor efficacy and safety characteristics of liposome-based Lx2-32c were explored and compared with those of cremophor-based Lx2-32c.

RESEARCH ARTICLE Preparation, Pharmacokinetics ...

Investigation of the Brain Biodistribution of the ...

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(PET) biodistribution study. ... The amended protocol was not initiated as the PET study was terminated due to a finding from a separate clinical pharmacology study ... were reviewed and approved by National Research Ethics Service of the UK National Health Service. The study was monitored in

Investigation of the Brain Biodistribution of the ...

Preclinical Potency and Biodistribution Studies of an AAV ...

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In Vivo Biodistribution Experiment in Rats. To study the biodistribution of the ART-I02 vector after local injection, arthritic and non-arthritic rats were injected in the right ankle joint and sacrificed one and four weeks later . The study was reviewed and approved by the animal care and use committee of the University of Amsterdam

Preclinical Potency and Biodistribution Studies of an AAV ...

International Journal of Peptides - Hindawi

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2.2. Biodistribution. The biodistribution was made using one male Wistar rat. In this direction, the Institutional Review Board and the Animal Ethics Committee approved the study protocol for this study. The labeled samples (3,7 MBq/0,2 mL) were administered after the catheterization of the jugular vein.

International Journal of Peptides - Hindawi

Preclinical good laboratory practice-compliant safety ...

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The whole study, consisting of biodistribution and tumorigenicity components, was performed under GLP ... All mice procedures were approved by the local ethics com-mittee for experimental animal studies (Landesdirektion Sachsen, A06/11) and thus were in accordance with the ... duced according to the co.don chondrosphere® protocol. Implantation ...

Preclinical good laboratory practice-compliant safety ...

Biodistribution and Radiation Dosimetry of 99mTc-HMPAO ...

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Because monocytes migrate 99mTc-HMPAO–labeled monocytes have biodistribution to inflamed joints, biodistribution could be slightly different and radiation dosimetry similar to those of 99mTc-HMPAO– in healthy volunteers or patients without active inflamma- labeled mixed WBCs and …

Biodistribution and Radiation Dosimetry of 99mTc-HMPAO ...

Biodistribution and radiation dosimetry of [64Cu]copper ...

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12/12/2017 · In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer.

Biodistribution and radiation dosimetry of [64Cu]copper ...

Therapeutic efficacy and biodistribution of allogeneic ...

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study was to evaluate long-term therapeutic efficacy and the biodistribution of allogeneic ADMSCs injected via two different routes of administration – intrasplenic (i.sp.) and intrapancreatic (i.pc.) – in a murine model of streptozoto-cin (STZ)-induced diabetes. Methods Experimental design Experiments were designed according to the protocol

Therapeutic efficacy and biodistribution of allogeneic ...

99mTc-labelled S-HYNIC certolizumab ... - EJNMMI Research

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12/12/2016 · Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab′-fragment directed against TNF. A biodistribution and dosimetry study was conducted. Tc-S-HYNIC CZP was synthesized.

99mTc-labelled S-HYNIC certolizumab ... - EJNMMI Research

Protocol - nejm.org

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Protocol This trial protocol has been provided by the authors to give readers additional information about their work. Protocol for: Nathwani AC, Tuddenham EGD, Rangarajan S, et al. Adenovirus ...

Protocol - nejm.org

Biodistribution and radiation dosimetry of the amyloid ...

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Biodistribution and Radiation Dosimetry of the Amyloid Imaging Agent 11C-PIB in Humans ˚ . ... PhD, P.O. Box The protocol of this study was approved by the local ethics 52, FIN-20521 Turku, Finland. ... the study protocol was A whole-body PET scan over the entire body was performed amended to include another 3 healthy control subjects (age, 78 ...

Biodistribution and radiation dosimetry of the amyloid ...

Quantitative Whole Body Biodistribution of Fluorescent ...

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When small molecules or proteins are injected into live animals, their physical and chemical properties will significantly affect pharmacokinetics, tissue penetration, and the ultimate routes of metabolism and clearance. Fluorescence molecular tomography (FMT) offers the ability to non-invasively image and quantify temporal changes in fluorescence throughout the major organ systems of living ...

Quantitative Whole Body Biodistribution of Fluorescent ...

Comparison of biodistribution profile of monoclonal ...

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The present study aimed to investigate and compare the biodistribution profiles of a monoclonal antibody PLA nano-particle and the aptamer anti-MUC1, both labeled with tech-netium-99m (99mTc) in experimental breast cancer model induced in animals. Study design In this study, three different formulations were used to test

Comparison of biodistribution profile of monoclonal ...

Exosomes promote restoration - SAGE Publications

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Ethics statement In this study, animal care and experimental procedures were strictly in accordance with the Guide for the Care and Use of Laboratory Animals, and the study was approved by the medical school of La Paz University Hospital’s Ethics Committee for the Care and Use of Animals in Research, according to the Spanish and

Exosomes promote restoration - SAGE Publications

Preclinical good laboratory practice-compliant safety ...

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5/20/2015 · The clinical development of advanced therapy medicinal products (ATMPs), a new class of drugs, requires initial safety studies that deviate from standard non-clinical safety protocols. The study provides a strategy to address the safety aspects of biodistribution and tumorigenicity of ATMPs under good laboratory practice (GLP) conditions avoiding cell product manipulation.

Preclinical good laboratory practice-compliant safety ...

[Full text] Development and characterization of a ...

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In vivo biodistribution study. The study was performed through cutaneous permeation of technetium-99m-labeled formulations. It was done after the approval of the study protocol (number 23076.020578/2013-27) by the Animal Experimentation Ethics Committee of the Federal University of Pernambuco (Brazil).

[Full text] Development and characterization of a ...

Research Paper Biodistribution and Localization of Iodine ...

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Biodistribution and Localization of Iodine-131-Labeled Metuximab in Patients with Hepatocellular Carcinoma ABSTRACT ... This study was designed to observe the biodistribution, localization and imaging characteristics of 131I -labeled Metuximab in 24 patients with HCC to determine the diagnositic and therapeutic potential of this antibody.

Research Paper Biodistribution and Localization of Iodine ...

A first-in-human study investigating biodistribution ...

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6/8/2018 · A first-in-human study investigating biodistribution, ... Of note, during the course of the study a protocol amendment was made to close the Arm A due to no clinical benefit observed in the first 3 patients and Arm C was never opened. ... Ethics approval and consent to participate.

A first-in-human study investigating biodistribution ...

Boron Neutron Capture Therapy of Brain Tumors ...

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9/1/2000 · The purpose of this study was to obtain tumor and normal brain tissue biodistribution data and pharmacokinetic profiles for sodium borocaptate (Na 2 B 12 H 11 SH) (BSH), a drug that has been used clinically in Europe and Japan for boron neutron capture therapy of brain tumors. The study was performed with a group of 25 patients who had preoperative diagnoses of either glioblastoma …

Boron Neutron Capture Therapy of Brain Tumors ...

Long-term in vivo biodistribution and toxicity study of ...

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7/13/2018 · Long-term in vivo biodistribution and toxicity study of functionalized near-infrared persistent luminescence nanoparticles Skip to main content Thank you for visiting nature.com.

Long-term in vivo biodistribution and toxicity study of ...
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