Carmelina study linagliptin dosage

Safety and efficacy of linagliptin in patients with type 2 ...

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The CArdiovascular and Renal Microvascular OutcomE Study With LINAgliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA®) (NCT01897532) trial will compare the CV and renal safety of linagliptin vs. placebo, added to standard care in patients with T2DM who are at high risk of vascular complications.

Safety and efficacy of linagliptin in patients with type 2 ...

MARLINA - T2D : Efficacy, Safety & Modification of ...

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MARLINA - T2D : Efficacy, Safety & Modification of Albuminuria in Type 2 Diabetes Subjects With Renal Disease With LINAgliptin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

MARLINA - T2D : Efficacy, Safety & Modification of ...

Tradjenta® (linagliptin) Tablets - Type 2 Diabetes ...

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TRADJENTA is an oral type 2 diabetes medication that can lower your A1C and blood sugar level. Talk to your doctor to see if TRADJENTA is right for you. View Important Safety Information, Prescribing Information and Medication Guide.

Tradjenta® (linagliptin) Tablets - Type 2 Diabetes ...

Effect of Linagliptin vs Placebo on Major Cardiovascular ...

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The CARMELINA®trial aims to evaluate the effects of linagliptin, a DPP-4 inhibitor, on both CV and kidney outcomes in a study population enriched for cardio-renal risk.

Effect of Linagliptin vs Placebo on Major Cardiovascular ...

Efficacy of anagliptin as compared to linagliptin on ...

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At present, randomized controlled clinical trials investigating the effects of linagliptin on CVD and renal function-the cardiovascular outcome study of linagliptin vs glimepiride in patients with type 2 diabetes (CAROLINA) and cardiovascular safety and renal microvascular outcome study with linagliptin (CARMELINA) trials[23,24] - are ongoing ...

Efficacy of anagliptin as compared to linagliptin on ...

The treatment of type 2 diabetes in the presence of renal ...

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6/23/2016 · The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies ... the Cardiovascular and Renal Microvascular Outcome Study with Linagliptin in Patients With Type 2 Diabetes ... such as CARMELINA, MARLINA, ELIXIRS, A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in ...

The treatment of type 2 diabetes in the presence of renal ...

Linagliptin as add‐on to empagliflozin in a fixed‐dose ...

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Linagliptin as add‐on to empagliflozin in a fixed‐dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a two‐part, randomized, placebo‐controlled trial ... Funding information This study was funded by Boehringer Ingelheim ... (CARMELINA …

Linagliptin as add‐on to empagliflozin in a fixed‐dose ...

Linagliptin and cardiovascular outcomes in type 2 diabetes ...

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1/4/2018 · The cardiovascular safety and efficacy of linagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS) or acute ischemic stroke (AIS) are unclear. The aim of our real-world cohort study was to evaluate the cardiovascular outcomes of linagliptin in patients with T2DM after ACS or AIS.

Linagliptin and cardiovascular outcomes in type 2 diabetes ...

Cardiovascular & Renal Microvascular Outcome Study With ...

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21 rows · CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, …

Cardiovascular & Renal Microvascular Outcome Study With ...

(PDF) Treatment With the Dipeptidyl Peptidase-4 Inhibitor ...

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Treatment With the Dipeptidyl Peptidase-4 Inhibitor Linagliptin or Placebo Followed by Glimepiride in Patients With Type 2 Diabetes With Moderate to Severe Renal Impairment: A 52-Week, Randomized ...

(PDF) Treatment With the Dipeptidyl Peptidase-4 Inhibitor ...

Empagliflozin as add‐on to linagliptin in a fixed‐dose ...

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Empagliflozin as add‐on to linagliptin in a fixed‐dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a 52‐week, randomized, placebo‐controlled trial

Empagliflozin as add‐on to linagliptin in a fixed‐dose ...

Review of the cardiovascular safety of dipeptidyl ...

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10/1/2018 · Thus, no dosage adjustment is required for linagliptin in patients with CKD, whereas sitaglptin, saxagliptin, ... et al. Rationale, design, and baseline characteristics of the CArdiovascular safety and renal microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with ...

Review of the cardiovascular safety of dipeptidyl ...

Linagliptin: from bench to bedside - PubMed Central (PMC)

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Linagliptin is a DPP-4 inhibitor approved in the US and elsewhere for the treatment of type 2 diabetes.8 Like others in the class, linagliptin is a competitive, reversible inhibitor of DPP-4.2,9 In contrast to other agents in the class,7 however, early studies in animal models demonstrated that linagliptin is almost completely (99%) bound to plasma proteins (mainly the DPP-4 enzyme) at the 5 ...

Linagliptin: from bench to bedside - PubMed Central (PMC)

Efficacy and Safety of Linagliptin in Subjects With Long ...

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11/1/2014 · The goal of the CARMELINA ® (Cardiovascular and Renal Microvascular Outcome Study with Linagliptin in Patients With Type 2 Diabetes Mellitus at High Vascular Risk; NCT01897532) study is to investigate the effects of linagliptin compared with placebo on major adverse cardiovascular events (time to first occurrence of cardiovascular death ...

Efficacy and Safety of Linagliptin in Subjects With Long ...

A randomised, active- and placebo-controlled, three-period ...

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A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 …

A randomised, active- and placebo-controlled, three-period ...

Nesina (alogliptin) dosing, indications, interactions ...

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Hospitalization for CHF was observed in 106 (3.9%) patients treated with alogliptin and 89 (3.3%) patients treated with placebo; although the difference was not statistically significant (hazard ratio, 1.19), heart failure was not an end point of the study

Nesina (alogliptin) dosing, indications, interactions ...

Efficacy and safety of linagliptin in subjects with type 2 ...

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The goal of the CARMELINA® (Cardiovascular and Renal ACKNOWLEDGMENTS Microvascular Outcome Study with Linagliptin in Pa- This work was supported by Boehringer Ingelheim tients With Type 2 Diabetes Mellitus at High Vascular Pharmaceuticals, Inc. Writing support was provided Risk; NCT01897532) study is to investigate the effects by Ann Kerrigan ...

Efficacy and safety of linagliptin in subjects with type 2 ...

Using DPP-4 inhibitors to modulate beta cell function in ...

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Infarction (TIMI-53)) [81,82]and the CARMELINA (Cardiovascular and Renal Microvascular Outcome Study with Linagliptin in Patients with Type 2 Mellitus) studies have spe-cifically investigated the effects of several DPP-4 inhibitors (sitagliptin, alogliptin, saxagliptin and linagliptin) on cardiovas-

Using DPP-4 inhibitors to modulate beta cell function in ...

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes ...

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The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. In this double-blind trial, we randomly ...

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes ...

Lilly, résultats actuels de Boehringer Ingelheim …

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10/5/2018 · Le profil de sécurité général du linagliptin dans CARMELINA ... avec un régime de dosage simple pour des adultes avec du diabète de type 2. ... Study suggests novel therapeutic strategy for ALS.

Lilly, résultats actuels de Boehringer Ingelheim …

Lesson: A Clinical Overview of DPP-4 Inhibitors for Type 2 ...

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10/1/2018 · ABSTRACT: Since the approval of the first dipeptidyl peptidase-4 (DPP-4) inhibitor in the United States in 2006, the use of these agents as second-line oral antihyperglycemic therapy in type 2 diabetes management has been established. Several clinical trials and meta-analyses have been conducted to identify potential additional benefits and risks associated with each DPP-4 inhibitor.

Lesson: A Clinical Overview of DPP-4 Inhibitors for Type 2 ...

The treatment of type 2 diabetes in the presence of renal ...

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1/5/2016 · The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies Melanie Davies,1,2 Sudesna Chatterjee,1,2 Kamlesh Khunti1,2 1Diabetes Research Centre, University of Leicester, 2Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, UK Abstract: Worldwide, an estimated 200 million people have chronic kidney …

The treatment of type 2 diabetes in the presence of renal ...

Linagliptin AND USA[Affiliation] Publications | PubFacts

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The CARMELINA trial aims to evaluate the effects of linagliptin, a DPP-4 inhibitor, on both CV and kidney outcomes in a study population enriched for cardio-renal risk. Methods: CARMELINA is a randomized, double-blind, placebo-controlled clinical trial conducted in 27 countries in T2D patients at high risk of CV and/or kidney events. Read More

Linagliptin AND USA[Affiliation] Publications | PubFacts

DPP-4 INHIBITORS - straighthealthcare.com

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Nested case-control study (BMJ 2016) [PubMed abstract] A nested case-control study published in 2016 compared the risk of pancreatic cancer among patients exposed to incretin mimetics (GLP-1 analogs and DPP-4 inhibitors) and those exposed to sulfonylureas. The study included 639 cases of pancreatic cancer who were matched with 8651 controls.

DPP-4 INHIBITORS - straighthealthcare.com

Efficacy and safety of linagliptin in Hispanic/Latino ...

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JAD is the study comparator study investigating the long-term cardiovas- guarantor. cular outcomes of linagliptin versus the commonly used Funding This work was supported by BIPI. sulfonylurea glimepiride.33 Of the 6000 patients included in CAROLINA, about 18% are of Hispanic/ Competing interests JAD has received consulting/advisory fees from ...

Efficacy and safety of linagliptin in Hispanic/Latino ...

Associate Professor of Medicine IU School of Medicine

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New treatments for an old disease Ahdy Wadie Helmy , MD, FACP Associate Professor of Medicine IU School of Medicine Type 2 Diabetes Mellitus

Associate Professor of Medicine IU School of Medicine

C D E R FOOD AND DRUG ADMINISTRATION DEPARTMENT OF …

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The attached package contains background information prepared by the Food and Drug Administration (FDA) for the panel members of the advisory committee.

C D E R FOOD AND DRUG ADMINISTRATION DEPARTMENT OF …

New Glucose-Lowering Agents for Diabetic Kidney Disease ...

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The prevalence of diabetes mellitus is increasing and is associated with a range of complications including nephropathy. New antidiabetic agents are sought which also have positive effects to diminish diabetic complications. Examples of promising new classes of such agents are glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter 2 ...

New Glucose-Lowering Agents for Diabetic Kidney Disease ...

Linagliptin: dpp-4 inhibition in the treatment of type 2 ...

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The results from a metanalysis involving trials from the large linagliptin Phase III programme support the hypothesis that linagliptin may have CV benefits in patients with T2DM. 19 Two large long-term studies are ongoing in order to evaluate the cardiovascular safety with the use of linagliptin (CAROLINA ® Study and CARMELINA TM) and its ...

Linagliptin: dpp-4 inhibition in the treatment of type 2 ...

Full text of "Linagliptin: from bench to bedside."

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